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JACC Basic Transl Sci. 2017 Jun;2(3):297-310. doi: 10.1016/j.jacbts.2016.11.009.

Metabolic Origins of Heart Failure.

Author information

1
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
2
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

Abstract

For more than half a century, metabolic perturbations have been explored in the failing myocardium, highlighting a reversion to a more fetal-like metabolic profile (characterized by depressed fatty acid oxidation and concomitant increased reliance on glucose utilization). More recently, alterations in ketone body and amino acid/protein metabolism have been described during heart failure, as well as mitochondrial dysfunction and perturbed metabolic signaling (e.g., acetylation, O-GlcNAcylation). Although numerous mechanisms are likely involved, the current review provides recent advances regarding the metabolic origins of heart failure, and their potential contribution toward contractile dysfunction of the heart.

KEYWORDS:

amino acids; fatty acids; glucose; heart failure; ketone bodies

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