Send to

Choose Destination
Intractable Rare Dis Res. 2017 Aug;6(3):158-162. doi: 10.5582/irdr.2017.01028.

Fetal pleural effusion and Down syndrome.

Cao L1, Du Y2, Wang L3,4,5.

Author information

Ultrasound Department, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Office of Clinical Epidemiology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, IBS, Fudan University Shanghai Medical College, Shanghai, China.
The Academy of Integrative Medicine of Fudan University, Shanghai, China.
Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases, Shanghai, China.


Fetal pleural effusion is a rare abnormality that results from accumulation of fluid in the chest cavity. It can be classified as primary fetal hydrothorax and secondary fetal hydrothorax. The underlying causes of pleural effusion are still unknown, and the current treatment strategies are mainly based on symptoms. The prognosis of fetal pleural effusion varies significantly, ranging from spontaneous resolution to perinatal death. Recent advances in prenatal diagnostic methods and treatment such as thoracoamniotic shunting have significantly improved the survival rates for patients with or without hydrops.


Down syndrome; Pleural effusion; diagnosis; etiology; prognosis; treatment

Supplemental Content

Full text links

Icon for IRCA-BSSA Group Icon for PubMed Central
Loading ...
Support Center