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J Neurochem. 1988 Apr;50(4):1322-4.

Occurrence of a large Ca2+-independent release of glutamate during anoxia in isolated nerve terminals (synaptosomes).

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1
Instituto de Bioquímica, Centro Mixto C.S.I.C.-U.C.M., Facultad de Farmacía, Universidad Complutense, Madrid, Spain.

Abstract

Isolated rat cerebral cortical synaptosomes made anoxic by addition of cyanide developed an inhibition of the Ca2+-dependent release of glutamate 2 min after the addition of the metabolic inhibitor when the intrasynaptosomal ATP/ADP ratio decreased below 1.7. In contrast, cyanide induced a continuous efflux of glutamate through a Ca2+-independent pathway that accounted for the release of 25% of total intrasynaptosomal glutamate in 5 min. The results suggest that a Ca2+-independent release of glutamate could be implicated in the neurotoxic action of this amino acid during anoxia.

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