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Environ Monit Assess. 2017 Sep 23;189(10):517. doi: 10.1007/s10661-017-6216-8.

Bisphenol A urinary level, its correlates, and association with cardiometabolic risks in Lebanese urban adults.

Author information

1
Kamal A. Shair Central Research Science Laboratory, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon.
2
Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
3
Department of Pharmacology and Toxicology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
4
Department of Nutrition and Food Sciences, Faculty of Agricultural and Food Sciences, American University of Beirut, Beirut, Lebanon.
5
Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
6
Vascular Medicine Program, American University of Beirut Medical Center, Beirut, Lebanon.
7
Clinical Research Institute, Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon. hani_t@hotmail.com.

Abstract

Bisphenol A (BPA) is an endocrine disruptor with multiple purported metabolic effects. This study aimed to measure BPA among Lebanese population, to identify its predictors, and to explore any link to metabolic disorders. A representative sample of 501 adults from Lebanon was recruited in a cross-sectional study. Urinary BPA was measured, and data were collected for anthropometric measurements, medical history, food intake, and laboratory markers of metabolic conditions. BPA data was divided into tertiles. A total of 89% of the subjects had detectable urinary BPA levels, with an overall mean of 3.67 ± 4.75 μg/L and a mean creatinine-adjusted BPA of 2.90 ± 4.79 μg/g. There was a significant positive association with female gender and older age for being in the highest BPA tertile. BPA level was linked to metabolic syndrome (MetS), obesity, type-2 diabetes (T2D), hypertension, and dyslipidemia. After adjustment, the trend remained for BPA in association with MetS and T2D. Though urinary BPA in the Lebanese population was higher in older women, the levels were similar to world-reported figures. Our results suggest a link with metabolic disorders but not at a significant level. These findings call for longitudinal and broader sample measurements.

KEYWORDS:

BPA; Cardiometabolic; Lebanon; Outcomes; Predictors; Urine

PMID:
28942470
DOI:
10.1007/s10661-017-6216-8
[Indexed for MEDLINE]

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