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Dev Med Child Neurol. 2018 Jan;60(1):47-53. doi: 10.1111/dmcn.13558. Epub 2017 Sep 21.

Preterm and term-equivalent age general movements and 1-year neurodevelopmental outcomes for infants born before 30 weeks' gestation.

Olsen JE1,2,3, Allinson LG1,4, Doyle LW1,2,3,5, Brown NC1,3, Lee KJ1,5, Eeles AL1,2, Cheong JLY1,2,3, Spittle AJ1,2,4.

Author information

1
Murdoch Childrens Research Institute, Melbourne, Victoria, Australia.
2
Newborn Research, Royal Women's Hospital, Parkville, Victoria, Australia.
3
Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Victoria, Australia.
4
Department of Physiotherapy, University of Melbourne, Melbourne, Victoria, Australia.
5
Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia.

Abstract

AIM:

To examine the associations between Prechtl's General Movements Assessment (GMA), conducted from birth to term-equivalent age, and neurodevelopmental outcomes at 12 months corrected age, in infants born very preterm.

METHOD:

One hundred and thirty-seven infants born before 30 weeks' gestation had serial GMA (categorized as 'normal' or 'abnormal') before term and at term-equivalent age. At 12 months corrected age, neurodevelopment was assessed using the Alberta Infant Motor Scale (AIMS); Neurological, Sensory, Motor, Developmental Assessment (NSMDA); and Touwen Infant Neurological Examination (TINE). The relationships between GMA at four time points and 12-month neurodevelopmental assessments were examined using regression models.

RESULTS:

Abnormal GMA at all time points were associated with worse continuous scores on the AIMS, NSMDA, and TINE (p<0.05). Abnormal GMA before term and at term-equivalent age were associated with increased odds of mild-severe dysfunction on the NSMDA (odds ratio [OR] 4.26, 95% confidence interval [CI] 1.55-11.71, p<0.01; and OR 4.16, 95% CI 1.55-11.17, p<0.01 respectively) and abnormal GMA before term with increased odds of suboptimal-abnormal motor function on the TINE (OR 2.75, 95% CI 1.10-6.85, p=0.03).

INTERPRETATION:

Abnormal GMA before term and at term-equivalent age were associated with worse neurodevelopment at 12 months corrected age in children born very preterm.

WHAT THIS PAPER ADDS:

Abnormal general movements before term predict developmental deficits at 1 year in infants born very preterm. General Movements Assessment before term identifies at-risk infants born very preterm.

PMID:
28940492
DOI:
10.1111/dmcn.13558
[Indexed for MEDLINE]
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