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Cancer Epidemiol Biomarkers Prev. 2017 Dec;26(12):1714-1721. doi: 10.1158/1055-9965.EPI-17-0496. Epub 2017 Sep 22.

Childhood Socioeconomic Position and Pubertal Onset in a Cohort of Multiethnic Girls: Implications for Breast Cancer.

Author information

1
Department of Epidemiology & Biostatistics, University of California, San Francisco, San Francisco, California. robert.hiatt@ucsf.edu.
2
Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California.
3
Department of Public Health Sciences, University of California, Davis, Davis, California.
4
Department of Epidemiology & Biostatistics, University of California, San Francisco, San Francisco, California.
5
Division of Research, Kaiser Permanente, Oakland, California.
6
Division of Environmental and Occupational Disease Control, California Department of Public Health, Richmond, California.
7
Department of Adolescent Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
8
Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio.
9
Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York.

Abstract

Background: Higher socioeconomic position (SEP) has been associated with increased risk of breast cancer. Its relationship with earlier age of pubertal onset, a risk factor for breast cancer, is less clear.Methods: We studied the relationship of SEP to pubertal onset in a multiethnic cohort of 1,237 girls ages 6 to 8 years at baseline. Girls in three U.S. cities were followed for 5 to 8 years with annual clinical examinations from 2004 to 2012. SEP measures were examined for associations with pubertal onset, assessed by breast budding (thelarche) and pubic hair development (adrenarche). Analyses were conducted with accelerated failure time models using a Weibull distribution, with left, right, and interval censoring.Results: Higher body mass index percentage at entry to the study and black or Hispanic race/ethnicity were the strongest predictors of age at pubertal onset. An SEP index comprising household family income, mother's education, and home ownership was an independent predictor of thelarche in adjusted models for all girls together and for white and Latina, separately, but not black girls, and the relationship varied by study site. The SEP index was not related to adrenarche in adjusted models. Overall, girls from the lowest quintile of SEP entered puberty on average 6% earlier than girls from the highest quintile (time ratio = 0.94; 95% confidence interval 0.91-0.97) in adjusted models.Conclusions: Our results suggest that early-life SEP may influence the timing of pubertal development.Impact: Factors related to lower SEP in childhood can adversely affect early development in ways that may increase the risk of breast cancer. Cancer Epidemiol Biomarkers Prev; 26(12); 1714-21. ©2017 AACR.

PMID:
28939588
PMCID:
PMC5712280
DOI:
10.1158/1055-9965.EPI-17-0496
[Indexed for MEDLINE]
Free PMC Article

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