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Brain Connect. 2017 Dec;7(10):671-682. doi: 10.1089/brain.2016.0476. Epub 2017 Nov 17.

Electroencephalographic Resting-State Networks: Source Localization of Microstates.

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1 Functional Brain Mapping Lab, University of Geneva , Geneva, Switzerland .
2 Center for Biomedical Imaging (CIBM) , Geneva, Switzerland .
3 Department of Radiology and Medical Informatics, University of Geneva , Geneva, Switzerland .
4 Institute of Bioengineering , EPFL, Lausanne, Switzerland .
5 CSAIL, Massachusetts Institute of Technology , Cambridge, Massachusetts.
6 Department of Radiology, Harvard Medical School and Brigham and Women's Hospital , Boston, Massachusetts.


Using electroencephalography (EEG) to elucidate the spontaneous activation of brain resting-state networks (RSNs) is nontrivial as the signal of interest is of low amplitude and it is difficult to distinguish the underlying neural sources. Using the principles of electric field topographical analysis, it is possible to estimate the meta-stable states of the brain (i.e., the resting-state topographies, so-called microstates). We estimated seven resting-state topographies explaining the EEG data set with k-means clustering (N = 164, 256 electrodes). Using a method specifically designed to localize the sources of broadband EEG scalp topographies by matching sensor and source space temporal patterns, we demonstrated that we can estimate the EEG RSNs reliably by measuring the reproducibility of our findings. After subtracting their mean from the seven EEG RSNs, we identified seven state-specific networks. The mean map includes regions known to be densely anatomically and functionally connected (superior frontal, superior parietal, insula, and anterior cingulate cortices). While the mean map can be interpreted as a "router," crosslinking multiple functional networks, the seven state-specific RSNs partly resemble and extend previous functional magnetic resonance imaging-based networks estimated as the hemodynamic correlates of four canonical EEG microstates.


EEG resting-state source localization; EEG source imaging; resting-state networks

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