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PLoS One. 2017 Sep 22;12(9):e0184625. doi: 10.1371/journal.pone.0184625. eCollection 2017.

[18F] FDOPA standardized uptake values of brain tumors are not exclusively dependent on LAT1 expression.

Author information

1
Department of Pathology, University Hospital, Nice, France.
2
UCA, Université Côte d'Azur, Nice-Sophia-Antipolis, France.
3
Department of Nuclear Medicine, Centre Antoine Lacassagne, Nice, France.
4
TIRO-UMR E 4320, University of Nice-Sophia-Antipolis, Nice, France.
5
Department of Neurosurgery, University Hospital, Nice, France.
6
UMR CNRS 7277-UMR INSERM 1091, Institute of Biology Valrose, University of Nice-Sophia-Antipolis, Nice, France.

Abstract

[18F]-FDOPA is a labeled amino acid (AA) analog used for positron emission tomography (PET) which is gaining increasing interest in the evaluation of brain tumors (BT). The AA-transporter LAT1 has been shown to be involved in [18F]-FDOPA uptake. The aim of this study was to determine whether the [18F]-FDOPA uptake was correlated with level of LAT1 expression in BT. Twenty-eight BT (including 19 gliomas and 9 metastases) were investigated by [18F]-FDOPA-PET prior to surgery and by anti-LAT1 immunohistochemistry on surgical specimens. The quantitative [18F]-FDOPA measured parameters were SUVmax, SUVmean and SUVpeak. LAT1 expression was quantified using a score (0 to 400). A significant [18F]-FDOPA uptake was associated with a LAT1 score ≥ 100 (p = 0.02) but there was no linear correlation between intensity of [18F]-FDOPA uptake and score of LAT1 expression whatever the parameters considered. LAT1 expression alone is not sufficient to explain variation of intensity of [18F]-FDOPA uptake in BT.

PMID:
28937983
PMCID:
PMC5609741
DOI:
10.1371/journal.pone.0184625
[Indexed for MEDLINE]
Free PMC Article

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