Format

Send to

Choose Destination
Environ Health Perspect. 2017 Sep 15;125(9):097014. doi: 10.1289/EHP1314.

Prenatal Exposure to Nonpersistent Endocrine Disruptors and Behavior in Boys at 3 and 5 Years.

Author information

1
Institute for Advanced Biosciences, INSERM U1209, CNRS UMR 5309, University Grenoble Alpes , Grenoble, France.
2
Centers for Disease Control and Prevention , Atlanta, Georgia, USA.
3
U1153 Epidemiology and Biostatistics Sorbonne Paris Cité Research Centre (CRESS) , Early Origin of the Child's Health and Development (ORCHAD) Team, Inserm, Villejuif, France.
4
Université Paris Descartes , Villejuif, France.
5
Faculty of Pharmacy, Université Paris-Sud, Université Paris-Saclay , Châtenay-Malabry, France.

Abstract

BACKGROUND:

Sex-specific associations have been reported between phthalates, bisphenol A (BPA), and child behavior. No data on large study populations are available for other phenols with possible endocrine-disrupting properties.

OBJECTIVES:

We aimed to study associations between prenatal exposure to phthalates and several phenols on behavior among male infants.

METHODS:

We quantified 11 phthalate metabolites and nine phenols (four parabens, benzophenone-3, BPA, two dichlorophenols, triclosan) in spot urine samples collected during pregnancy among EDEN cohort mothers who delivered a boy. Mothers completed the Strength and Difficulties Questionnaire (SDQ) when their children were 3.1 (n=529) and 5.6 (n=464) y old.

RESULTS:

BPA was positively associated with the relationship problems subscale at 3 y [incidence rate ratio (IRR): 1.11; 95% confidence interval (CI): 1.03, 1.20] and the hyperactivity-inattention subscale scores at 5 y (IRR: 1.08; 95% CI: 1.01, 1.14). Mono-n-butyl phthalate (MnBP) was positively associated with internalizing behavior, relationship problem, and emotional symptom scores at 3 y. Monobenzyl phthalate (MBzP) was positively associated with internalizing behavior and relationship problems scores at 3 y. After dichotomizing SDQ scores, triclosan tended to be positively associated with emotional symptom subscales at both 3 and 5 y.

CONCLUSIONS:

The observed associations between BPA, MnBP, and behavior in boys are consistent with previous findings. Further health impact assessment studies based on dose-response functions corrected for exposure misclassification are required to quantify the public health burden possibly entailed by such associations. https://doi.org/10.1289/EHP1314.

PMID:
28937960
PMCID:
PMC5915182
DOI:
10.1289/EHP1314
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Atypon Icon for PubMed Central
Loading ...
Support Center