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Curr Opin Pediatr. 2017 Dec;29(6):697-703. doi: 10.1097/MOP.0000000000000554.

Non-IgE-mediated gastrointestinal food allergies.

Author information

1
aDivision of Pediatric Allergy, Department of Pediatrics, University Hospitals of Geneva, Geneva, Switzerland bPediatric Allergy Division, Hôpital Femme-Mère-Enfant, Université de Lyon Est, Lyon, France cDivision of Pediatric Allergy, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Abstract

PURPOSE OF REVIEW:

We focus on recent advances regarding the epidemiology, physiopathology, diagnosis and managements of non-IgE-mediated gastrointestinal food allergies (non-IgE-GI-FAs), particularly food protein-induced enterocolitis syndrome (FPIES).

RECENT FINDINGS:

The first international FPIES diagnostic and management guidelines have been recently published. Although FPIES largely remains a diagnosis of exclusion, it may be more prevalent than previously thought. Ondansetron has emerged as a major tool for the treatment of FPIES acute reactions. Recent data also suggest an important role for innate immune cells in FPIES pathogenesis.

SUMMARY:

Despite major advances in the diagnosis and management of non-IgE-GI-FAs, particularly FPIES, the lack of specific diagnostic tests and biomarkers to guide clinical management remains challenging.

PMID:
28937509
DOI:
10.1097/MOP.0000000000000554
[Indexed for MEDLINE]

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