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Hum Vaccin Immunother. 2017 Dec 2;13(12):2977-2981. doi: 10.1080/21645515.2017.1371377. Epub 2017 Sep 21.

Q-vaxcelerate: A distributed development approach for a new Coxiella burnetii vaccine.

Author information

1
a Vaccine and Immunotherapy Center, Division of Infectious Diseases, Department of Medicine , Massachusetts General Hospital , Boston , MA , USA.

Abstract

Development of vaccines that are both safe and effective remains a costly and time-consuming challenge. To accelerate the pace of development and improve the efficacy and safety of candidate vaccines for both existing and emerging infectious agents, we have used a distributed development approach. This features the managed integration of individual expert groups having the requisite vaccine platforms, pre-clinical models, assays, skills and knowledge pertinent to a specific pathogen into a single, end-to-end development team capable of producing a new vaccine tailored to that particular agent. Distributed development focuses on integrating existing effort across multiple institutions rather than developing new capabilities or consolidating resources within an individual organization. Previously we have used the distributed development strategy to generate vaccine candidates for emerging viral diseases. Coxiella burnetii is a highly infectious and resilient bacterium and the causative agent of Q fever. Treatment for Q fever can require months of antibiotics. The current vaccine for Q-fever is only approved in Australia and requires prescreening due to the potential for severe reactogenicity in previously exposed individuals. Here we discuss Q-VaxCelerate, a distributed development consortium for the development of a new vaccine to prevent Q fever.

KEYWORDS:

Coxiella burnetii; Qfever; distribute development; peptide; subunit; vaccine

PMID:
28933682
PMCID:
PMC5718828
DOI:
10.1080/21645515.2017.1371377
[Indexed for MEDLINE]
Free PMC Article

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