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Neurology. 1988 Feb;38(2):219-22.

Intraventricular bethanechol infusion for Alzheimer's disease: results of double-blind and escalating-dose trials.

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1
Department of Neurological Surgery, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612.

Abstract

Ten patients with biopsy-proven Alzheimer's disease (AD) received low-dose (0.35 mg/d) intraventricular bethanechol, a muscarinic agonist, and saline placebo in a 24-week double-blind crossover design. Eight of these ten patients later participated in an open escalating-dose (to 1.75 mg/d) trial of bethanechol. Patients' drug responses were assessed by neuropsychological examination and informant measures of activities of daily living, mood disturbance, and abnormal behavior. Bethanechol appears to have a narrow therapeutic window for positive effects; low doses did not reliably alter patient functioning, moderately increased doses appeared to have a palliative effect on patient mood and behavior, and the highest dose was detrimental to patient functioning. Bethanechol does not appear to ameliorate the dementia of AD, but may exert a mildly positive effect on patient behavior and mood.

PMID:
2893314
[Indexed for MEDLINE]
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