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Curr Cardiol Rep. 2017 Sep 20;19(11):111. doi: 10.1007/s11886-017-0919-x.

Psychological Stress, Inflammation, and Coronary Heart Disease.

Author information

1
Biological Work and Health Psychology, Department of Psychology, University of Konstanz, Universitaetsstrasse 10, 78457, Constance, Baden-Wuerttemberg, Germany. petra.wirtz@uni-konstanz.de.
2
Department of Neurology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.

Abstract

PURPOSE OF REVIEW:

In this review, we summarize evidence on the risk factor psychological stress in the context of coronary heart disease (CHD) in humans and explore the role of inflammation as a potential underlying mechanism.

RECENT FINDINGS:

While chronic stress increases the risk of incident CHD and poor cardiovascular prognosis, acute emotional stress can trigger acute CHD events in vulnerable patients. Evidence supporting a potential role for inflammation as a promising biological mechanism comes from population-based studies showing associations between chronic stress and increased inflammation. Similarly, experimental studies demonstrate acute stress-induced increases in inflammatory markers and suggest modulatory potential for pharmacological and biobehavioral interventions. So far, studies investigating patients with cardiovascular disease are few and the full sequence of events from stress to inflammation to CHD remains to be established. Psychological stress is an independent CHD risk factor associated with increased inflammation. Although promising, causality needs to be further explored.

KEYWORDS:

C-reactive protein; Coronary heart disease; Cytokines; Exhaustion; Inflammation; Inflammatory stress response; Interleukin; Intervention; Job burnout; Psychosocial stress

PMID:
28932967
DOI:
10.1007/s11886-017-0919-x
[Indexed for MEDLINE]

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