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Neuropsychiatr Dis Treat. 2017 Sep 8;13:2357-2362. doi: 10.2147/NDT.S138289. eCollection 2017.

Natural reduced water suppressed anxiety and protected the heightened oxidative stress in rats.

Author information

1
Department of Neuropsychiatry, Oita University Faculty of Medicine, Hasama-Machi, Oita, Japan.

Abstract

BACKGROUND:

In Japan, the effects of reduced water, such as hydrogen-rich electrolyzed reduced water and natural reduced water, like Hita Tenryosui water®, have been examined. The purpose of the present study was to identify the role of natural reduced water in anxiety and blood biochemical analysis.

MATERIALS AND METHODS:

Natural reduced water and distilled water were administered to rats for 180 consecutive days, and their effect on anxiety-like behavior and depression was examined by using elevated plus maze, light/dark, forced swimming, and conditioned fear tests. Before and after administration of natural reduced or distilled water, we performed blood and urine analyses.

RESULTS:

Natural reduced water exhibited anxiolytic-like effects in the conditioned fear and elevated plus maze tests. The mean levels of urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) in the natural reduced water were significantly lower than the distilled water group. Natural reduced water group also showed decrease in blood-urea nitrogen levels compared with the distilled water group.

CONCLUSION:

These results indicate that natural reduced water may decrease anxiety-related behaviors and prevent heightened oxidative stress.

KEYWORDS:

8-OHdG; Hita Tenryosui; conditioned fear; depression; elevated plus maze; urea nitrogen

Conflict of interest statement

Disclosure Dr Akiyoshi has received unrestricted research grants from Hita Tenryosui Co., Ltd. The authors report no other conflicts of interest in this work.

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