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Clin Interv Aging. 2017 Sep 8;12:1419-1428. doi: 10.2147/CIA.S145247. eCollection 2017.

Cognitive and behavioral evaluation of nutritional interventions in rodent models of brain aging and dementia.

Author information

1
Charles Perkins Centre, University of Sydney, Sydney.
2
Aging and Alzheimers Institute, ANZAC Research Institute, Concord Clinical School/Sydney Medical School, Concord, NSW, Australia.
3
Department of Renewable Resources, University of Alberta, Edmonton, AB, Canada.
4
Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
5
Philadelphia College of Osteopathic Medicine, Philadelphia, PA, USA.
6
Faculty of Veterinary Science.
7
School of Life and Environmental Sciences, University of Sydney, Sydney, NSW, Australia.
8
Laboratory of Neurosciences, National Institute on Aging's Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.

Abstract

Evaluation of behavior and cognition in rodent models underpins mechanistic and interventional studies of brain aging and neurodegenerative diseases, especially dementia. Commonly used tests include Morris water maze, Barnes maze, object recognition, fear conditioning, radial arm water maze, and Y maze. Each of these tests reflects some aspects of human memory including episodic memory, recognition memory, semantic memory, spatial memory, and emotional memory. Although most interventional studies in rodent models of dementia have focused on pharmacological agents, there are an increasing number of studies that have evaluated nutritional interventions including caloric restriction, intermittent fasting, and manipulation of macronutrients. Dietary interventions have been shown to influence various cognitive and behavioral tests in rodents indicating that nutrition can influence brain aging and possibly neurodegeneration.

KEYWORDS:

aging; calorie restriction; intermittent fasting; macronutrients; memory

PMID:
28932108
PMCID:
PMC5598548
DOI:
10.2147/CIA.S145247
[Indexed for MEDLINE]
Free PMC Article

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