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Sci Rep. 2017 Sep 20;7(1):11955. doi: 10.1038/s41598-017-12109-9.

Effect of caloric restriction on gut permeability, inflammation markers, and fecal microbiota in obese women.

Author information

1
Else Kröner-Fresenius-Center of Nutritional Medicine, Technical University of Munich, Freising, Germany.
2
ZIEL Institute for Food and Health, Technical University of Munich, Freising-Weihenstephan, Germany.
3
Charité-Universitätsmedizin, Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie, Berlin, Germany.
4
Institute of Medical Microbiology, RWTH University Hospital, Aachen, Germany.
5
Chair of Analytical Food Chemistry, Technical University of Munich, Freising, Germany.
6
Chair of Nutrition and Immunology, Technical University of Munich, Freising-Weihenstephan, Germany.
7
Else Kröner-Fresenius-Center of Nutritional Medicine, Technical University of Munich, Freising, Germany. hans.hauner@tum.de.
8
ZIEL Institute for Food and Health, Technical University of Munich, Freising-Weihenstephan, Germany. hans.hauner@tum.de.
9
Institute of Nutritional Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany. hans.hauner@tum.de.

Abstract

Recent findings suggest an association between obesity, loss of gut barrier function and changes in microbiota profiles. Our primary objective was to examine the effect of caloric restriction and subsequent weight reduction on gut permeability in obese women. The impact on inflammatory markers and fecal microbiota was also investigated. The 4-week very-low calorie diet (VLCD, 800 kcal/day) induced a mean weight loss of 6.9 ± 1.9 kg accompanied by a reduction in HOMA-IR (Homeostasis model assessment-insulin resistance), fasting plasma glucose and insulin, plasma leptin, and leptin gene expression in subcutaneous adipose tissue. Plasma high-molecular weight adiponectin (HMW adiponectin) was significantly increased after VLCD. Plasma levels of high-sensitivity C-reactive protein (hsCRP) and lipopolysaccharide-binding protein (LBP) were significantly decreased after 28 days of VLCD. Using three different methods, gut paracellular permeability was decreased after VLCD. These changes in clinical parameters were not associated with major consistent changes in dominant bacterial communities in feces. In summary, a 4-week caloric restriction resulted in significant weight loss, improved gut barrier integrity and reduced systemic inflammation in obese women.

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