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Neurology. 2017 Oct 17;89(16):1716-1722. doi: 10.1212/WNL.0000000000004517. Epub 2017 Sep 20.

Serum magnesium is associated with the risk of dementia.

Author information

1
From the Departments of Epidemiology (B.C.T.K., S.L., F.J.W., M.K.I., B.H.S., M.A.I.), Internal Medicine (B.C.T.K., E.J.H., R.Z., B.H.S.), and Neurology (S.L., F.J.W., M.K.I.), Erasmus MC-University Medical Center Rotterdam; and Inspectorate of Health Care (B.C.T.K., B.H.S.), Utrecht, the Netherlands.
2
From the Departments of Epidemiology (B.C.T.K., S.L., F.J.W., M.K.I., B.H.S., M.A.I.), Internal Medicine (B.C.T.K., E.J.H., R.Z., B.H.S.), and Neurology (S.L., F.J.W., M.K.I.), Erasmus MC-University Medical Center Rotterdam; and Inspectorate of Health Care (B.C.T.K., B.H.S.), Utrecht, the Netherlands. b.stricker@erasmusmc.nl.

Abstract

OBJECTIVE:

To determine if serum magnesium levels are associated with the risk of all-cause dementia and Alzheimer disease.

METHODS:

Within the prospective population-based Rotterdam Study, we measured serum magnesium levels in 9,569 participants, free from dementia at baseline (1997-2008). Participants were subsequently followed up for incident dementia, determined according to the DSM-III-R criteria, until January 1, 2015. We used Cox proportional hazard regression models to associate quintiles of serum magnesium with incident all-cause dementia. We used the third quintile as a reference group and adjusted for age, sex, Rotterdam Study cohort, educational level, cardiovascular risk factors, kidney function, comorbidities, other electrolytes, and diuretic use.

RESULTS:

Our study population had a mean age of 64.9 years and 56.6% were women. During a median follow-up of 7.8 years, 823 participants were diagnosed with all-cause dementia. Both low serum magnesium levels (≤0.79 mmol/L) and high serum magnesium levels (≥0.90 mmol/L) were associated with an increased risk of dementia (hazard ratio [HR] 1.32, 95% confidence interval [CI] 1.02-1.69, and HR 1.30, 95% CI 1.02-1.67, respectively).

CONCLUSIONS:

Both low and high serum magnesium levels are associated with an increased risk of all-cause dementia. Our results warrant replication in other population-based studies.

PMID:
28931641
DOI:
10.1212/WNL.0000000000004517
[Indexed for MEDLINE]

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