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J Expo Sci Environ Epidemiol. 2018 Jan;28(1):31-39. doi: 10.1038/jes.2017.22. Epub 2017 Sep 20.

Comparison of questionnaire-based estimation of pesticide residue intake from fruits and vegetables with urinary concentrations of pesticide biomarkers.

Author information

1
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
2
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
3
Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
4
Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
5
Environmental Influences on Child Health Outcomes Program, Office of the Director, National Institutes of Health, Rockville, Maryland, USA.
6
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
7
National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
8
Vincent Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts, USA.

Abstract

We developed a pesticide residue burden score (PRBS) based on a food frequency questionnaire and surveillance data on food pesticide residues to characterize dietary exposure over the past year. In the present study, we evaluated the association of the PRBS with urinary concentrations of pesticide biomarkers. Fruit and vegetable (FV) intake was classified as having high (PRBS≥4) or low (PRBS<4) pesticide residues for 90 men from the EARTH study. Two urine samples per man were analyzed for seven biomarkers of organophosphate and pyrethroid insecticides, and the herbicide 2,4-dichlorophenoxyacetic acid. We used generalized estimating equations to analyze the association of the PRBS with urinary concentrations of pesticide biomarkers. Urinary concentrations of pesticide biomarkers were positively related to high pesticide FV intake but inversely related to low pesticide FV intake. The molar sum of urinary concentrations of pesticide biomarkers was 21% (95% confidence interval (CI): 2%, 44%) higher for each one serving/day increase in high pesticide FV intake, and 10% (95% CI: 1%, 18%) lower for each one serving/day increase in low pesticide FV intake. Furthermore, intake of high pesticide FVs positively related to most individual urinary biomarkers. Our findings support the usefulness of the PRBS approach to characterize dietary exposure to select pesticides.

PMID:
28930298
PMCID:
PMC5734986
[Available on 2019-01-01]
DOI:
10.1038/jes.2017.22
[Indexed for MEDLINE]

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