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Nutrients. 2017 Sep 20;9(9). pii: E1036. doi: 10.3390/nu9091036.

Red Blood Cell Eicosapentaenoic Acid Inversely Relates to MRI-Assessed Carotid Plaque Lipid Core Burden in Elders at High Cardiovascular Risk.

Author information

1
Radiology Department, Clinical Diagnostic Imaging Centre, Institut d'Investigacions Biomèdiques August i Sunyer, Hospital Clínic, 08036 Barcelona, Spain; bargalloclinic.ub.es (N.B.). gilabert@clinic.ub.es.
2
Magnetic Resonance Image Core Facility, Institut d'Investigacions Biomèdiques August i Sunyer, 08036 Barcelona, Spain. gilabert@clinic.ub.es.
3
Radiology Department, Clinical Diagnostic Imaging Centre, Institut d'Investigacions Biomèdiques August i Sunyer, Hospital Clínic, 08036 Barcelona, Spain; bargalloclinic.ub.es (N.B.).
4
Department of Internal Medicine, Institut d'Investigacions Biomèdiques August i Sunyer, Hospital Clínic, 08036 Barcelona, Spain. eromero@hotmail.com.
5
Ciber Fisiopatología de la Obesidad y Nutrición , Instituto de Salud Carlos III, 28039 Madrid, Spain. mcofan@clinic.cat.
6
Lipid Clinic, Department of Endocrinology and Nutrition, Institut d'Investigacions Biomèdiques August i Sunyer, Hospital Clínic, 08036 Barcelona, Spain. mcofan@clinic.cat.
7
Human Development and Health Academic Unit, University of Southampton, Southampton SO16 6YD, UK. P.C.Calder@soton.ac.uk.
8
NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Fundation Trust, Southampton SO16 6YD, UK. P.C.Calder@soton.ac.uk.
9
Ciber Fisiopatología de la Obesidad y Nutrición , Instituto de Salud Carlos III, 28039 Madrid, Spain. mfito@imim.es.
10
Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona Biomedical Research Park, 08003 Barcelona, Spain. mfito@imim.es.
11
Ciber Fisiopatología de la Obesidad y Nutrición , Instituto de Salud Carlos III, 28039 Madrid, Spain. dolores.corella@uv.es.
12
Department of Preventive Medicine, University of Valencia, 46010 Valencia, Spain. dolores.corella@uv.es.
13
Ciber Fisiopatología de la Obesidad y Nutrición , Instituto de Salud Carlos III, 28039 Madrid, Spain. jordi.salas@urv.cat.
14
Human Nutrition Department, Hospital Universitari Sant Joan, Institut d'Investigació Sanitaria Pere Virgili, Universitat Rovira i Virgili, 43201 Reus, Spain. jordi.salas@urv.cat.
15
Ciber Fisiopatología de la Obesidad y Nutrición , Instituto de Salud Carlos III, 28039 Madrid, Spain. mcanela@unav.es.
16
Department of Preventive Medicine and Public Health, University of Navarra, 31080 Pamplona, Spain. mcanela@unav.es.
17
Department of Internal Medicine, Institut d'Investigacions Biomèdiques August i Sunyer, Hospital Clínic, 08036 Barcelona, Spain. restruch@clinic.cat.
18
Ciber Fisiopatología de la Obesidad y Nutrición , Instituto de Salud Carlos III, 28039 Madrid, Spain. restruch@clinic.cat.
19
Ciber Fisiopatología de la Obesidad y Nutrición , Instituto de Salud Carlos III, 28039 Madrid, Spain. eros@clinic.ub.es.
20
Lipid Clinic, Department of Endocrinology and Nutrition, Institut d'Investigacions Biomèdiques August i Sunyer, Hospital Clínic, 08036 Barcelona, Spain. eros@clinic.ub.es.
21
Ciber Fisiopatología de la Obesidad y Nutrición , Instituto de Salud Carlos III, 28039 Madrid, Spain. asala@clinic.ub.es.
22
Lipid Clinic, Department of Endocrinology and Nutrition, Institut d'Investigacions Biomèdiques August i Sunyer, Hospital Clínic, 08036 Barcelona, Spain. asala@clinic.ub.es.

Abstract

Supplemental marine omega-3 eicosapentaenoic acid (EPA) has an anti-atherosclerotic effect. Clinical research on EPA supplied by the regular diet and atherosclerosis is scarce. In the framework of the PREvención con DIeta MEDiterránea (PREDIMED) trial, we conducted a cross-sectional study in 161 older individuals at high vascular risk grouped into different stages of carotid atherosclerosis severity, including those without ultrasound-detected atheroma plaque (n = 38), with plaques <2.0 mm thick (n = 65), and with plaques ≥2.0 mm (n = 79). The latter were asked to undergo contrast-enhanced 3T magnetic resonance imaging (MRI) and were subsequently grouped into absence (n = 31) or presence (n = 27) of MRI-detectable plaque lipid, a main feature of unstable atheroma plaques. We determined the red blood cell (RBC) proportion of EPA (a valid marker of long-term EPA intake) at enrolment by gas chromatography. In multivariate models, EPA related inversely to MRI-assessed plaque lipid volume, but not to maximum intima-media thickness of internal carotid artery, plaque burden, or MRI-assessed normalized wall index. The inverse association between EPA and plaque lipid content in patients with advanced atherosclerosis supports the notion that this fatty acid might improve cardiovascular health through stabilization of advanced atheroma plaques.

KEYWORDS:

atherosclerosis; diet; fish; imaging; omega-3

PMID:
28930197
PMCID:
PMC5622796
DOI:
10.3390/nu9091036
[Indexed for MEDLINE]
Free PMC Article

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