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AJR Am J Roentgenol. 2017 Dec;209(6):1390-1395. doi: 10.2214/AJR.16.17603. Epub 2017 Sep 20.

Ethanol-Gel Sclerotherapy of Venous Malformations: Effectiveness and Safety.

Author information

1
1 Department of Radiology, University Medical Center Regensburg, 93042 Regensburg, Germany.
2
2 Fürst Medical Laboratory, Oslo, Norway.
3
3 Present address: Bioscientia Institute for Medical Diagnostics GmbH, Karlsfeld, Germany.

Abstract

OBJECTIVE:

In the treatment of venous malformations, ethanol may be administered in a gelified form to increase local effects and reduce systemic ones. The purpose of this prospective study was to evaluate the efficacy and safety of a commercially available viscous ethanol gel in the treatment of venous malformations.

SUBJECTS AND METHODS:

Thirty-one patients (mean age, 23.4 years; age range, 6.6-46.5 years) with venous malformations were prospectively scheduled for two ethanol-gel sclerotherapy sessions. Venous malformations were located at the lower extremity (n = 18), the upper extremity (n = 9), and the face (n = 4). Questionnaires to assess pain, clinical examinations, professional photographs, and contrast-enhanced MRI of the venous malformations were performed before and after therapy to measure therapy-induced changes. Two experienced radiologists blinded to the examination date and clinical status compared photographs and MR images before and after treatment.

RESULTS:

A mean of 4.2 mL of ethanol gel were administered per session. The technical success rate was 100%. Clinical success, defined as improvement or resolution of symptoms, was noted in 81% of patients. Mean pain score decreased, and the difference was statistically significant (3.9 vs 3.1, p = 0.005). In 54 treatment sessions where follow-up was available, four minor complications occurred. Comparison of photographs and MR images before and after treatment showed improvement in 35% and 93% of patients, respectively.

CONCLUSION:

Ethanol gel is an effective and safe sclerosing agent in the treatment of venous malformations.

KEYWORDS:

ethanol gel; sclerotherapy; venous malformation

PMID:
28929808
DOI:
10.2214/AJR.16.17603
[Indexed for MEDLINE]

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