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Breast J. 2018 Jan;24(1):66-69. doi: 10.1111/tbj.12843. Epub 2017 Sep 19.

Characteristics and clinical outcomes of pleomorphic lobular carcinoma in situ of the breast.

Author information

1
Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA.
2
Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
3
Department of Pathology, VA Palo Alto Health Care System, Palo Alto, CA, USA.

Abstract

Pleomorphic lobular carcinoma in situ (PLCIS) of the breast is a rare variant of lobular carcinoma in situ (LCIS). We reviewed 78 cases of PLCIS diagnosed at our institution from 1998 to 2012. Among all cases, 47 (60%) were associated with invasive carcinoma and/or ductal carcinoma in situ (DCIS) after final surgical excision. Of the 20 cases with PLCIS alone on core needle biopsy (CNB), 6 (30%) were upgraded to invasive carcinoma or DCIS after final surgical excision. Our findings support a recommendation for complete surgical excision of PLCIS when diagnosed on CNB.

KEYWORDS:

breast disease; pleomorphic lobular carcinoma in situ; surgical margins

PMID:
28929550
DOI:
10.1111/tbj.12843
[Indexed for MEDLINE]

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