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Amino Acids. 2017 Dec;49(12):2091-2098. doi: 10.1007/s00726-017-2494-2. Epub 2017 Sep 19.

The role of methionine on metabolism, oxidative stress, and diseases.

Martínez Y1,2,3, Li X1,2, Liu G4,5, Bin P1,2, Yan W1,2, Más D6, Valdivié M7, Hu CA1,2,8,9, Ren W1,2, Yin Y1,2,9.

Author information

1
Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, 410125, Hunan, China.
2
National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, 410125, Hunan, China.
3
Department of Animal Production, Faculty of Veterinary Medicine, Agricultural University of Havana, 32700, San José de Las Lajas, Mayabeque, Cuba.
4
Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, 410125, Hunan, China. gangle.liu@gmail.com.
5
National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, 410125, Hunan, China. gangle.liu@gmail.com.
6
Faculty of Natural Sciences, University of Queretaro, Querétaro, Mexico.
7
Department of Management and Feeding of Monogastric Animals, Institute of Animal Science, 32700, San José de Las Lajas, Mayabeque, Cuba.
8
Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, MSC08 4670, Fitz 258, Albuquerque, NM, 87131, USA.
9
Animal Nutrition and Human Health Laboratory, School of Life Sciences, Hunan Normal University, Changsha, 410081, Hunan, China.

Abstract

Methionine is an aliphatic, sulfur-containing, essential amino acid, and a precursor of succinyl-CoA, homocysteine, cysteine, creatine, and carnitine. Recent research has demonstrated that methionine can regulate metabolic processes, the innate immune system, and digestive functioning in mammals. It also intervenes in lipid metabolism, activation of endogenous antioxidant enzymes such as methionine sulfoxide reductase A, and the biosynthesis of glutathione to counteract oxidative stress. In addition, methionine restriction prevents altered methionine/transmethylation metabolism, thereby decreasing DNA damage and carcinogenic processes and possibly preventing arterial, neuropsychiatric, and neurodegenerative diseases. This review focuses on the role of methionine in metabolism, oxidative stress, and related diseases.

KEYWORDS:

Cancer; Disease; Endogenous antioxidant enzyme; Mammalian; Methionine; ROS

PMID:
28929442
DOI:
10.1007/s00726-017-2494-2
[Indexed for MEDLINE]

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