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J Biol Phys. 2017 Dec;43(4):551-563. doi: 10.1007/s10867-017-9469-0. Epub 2017 Sep 19.

Gibbs free energy as a measure of complexity correlates with time within C. elegans embryonic development.

Author information

1
College of Information and Computer Sciences, University of Massachusetts Amherst, Amherst, MA, USA.
2
Department of Oncology, Cross Cancer Institute, University of Alberta Edmonton, Edmonton, Alberta, Canada. jackt@ualberta.ca.
3
Department of Physics, University Of Alberta, Edmonton, Alberta, TG6 2J1, Canada. jackt@ualberta.ca.

Abstract

We investigate free energy behavior in the nematode Caenorhabditis elegans during embryonic development. Our approach utilizes publicly available gene expression data, which gives us a picture of developmental changes in protein concentration and, resultantly, chemical potential and free energy. Our results indicate a clear global relationship between Gibbs free energy and time spent in development and provide thermodynamic indicators of the large-scale biological events of cell division and differentiation.

KEYWORDS:

Development; Entropy; Gibbs free energy; Protein-protein interaction networks

PMID:
28929407
PMCID:
PMC5696307
[Available on 2018-12-01]
DOI:
10.1007/s10867-017-9469-0
[Indexed for MEDLINE]

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