Format

Send to

Choose Destination
J Cancer. 2017 Aug 25;8(15):2950-2958. doi: 10.7150/jca.20496. eCollection 2017.

Vulvar Cancer in China: Epidemiological Features and Risk Analysis.

Author information

1
Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu 610041, P.R.China.
2
Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston, Texas.
3
Department of Gynaecology and Obstetrics, ZiYang maternal and child health care hospital, West China Second University Union-hospital, Ziyang, P.R.China.
4
Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Chengdu 610041, P.R.China.
5
Department of Gynaecology and Obstetritics, MeiShan City People's Hospital, Meishan 620010, P.R. China.
6
West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, P.R. China.
7
Department of Pathology, West China Second University Hospital, Sichuan University, Chengdu 610041, P.R.China.
8
The Oak Ridge Institute for Science and Education, USA.
9
Laboratory of Genetics, West China Institute of Women and Children's Health, West China Second Hospital, Sichuan University, Chengdu 610041, P.R.China.

Abstract

Objective: Describe for the first time the clinical, epidemiological features of vulvar cancer in southwest China. Identify risk factors and provide reference for the prevention of vulvar cancer. Method: We retrospectively analyzed 885 patients admitted to the West China Second University Hospital for vulvar diseases between 2006 and 2016. Vulvar cancer patients with previously diagnosed vulvar nonneoplastic epithelial disorders (n=132) were analyzed and compared to those without prior history of vulvar nonneoplastic epithelial disorders (n=219). Comparisons were also made among cancer patients and non-cancer patients with vulvar nonneoplastic epithelial disorders (n=288) and vulvar squamous intraepithelial lesions (n=246). The risk factors leading to vulvar cancer for the patients with vulvar nonneoplastic epithelial disorder were analyzed by univariate analysis. Furthermore, differences of the epidemiological features of vulvar nonneoplastic epithelial disorders, vulvar squamous intraepithelial lesion and vulvar cancer were identified. Results: According to the univariate analysis, age, first coital age, educational level, smoking, history of vaginal atrophy, HPV infection, lesion sites of the upper vulva and histo-pathological changes are strongly positively correlated with vulvar cancer. By comparing the features of vulvar cancer with those of the vulvar nonneoplastic epithelial disorder and vulvar squamous intraepithelial lesion, we found that on average patients with vulvar cancer had the highest age (ranged from 50 to 59), the lowest first coital age and the highest number of pregnancies and births. The incidences of vulvar nonneoplastic epithelial disorder and vulvar cancer were 1/1000 and 2.5/100,000 respectively with an increasing trend during last 10 years. Conclusion: Age, first coital age, educational level, smoking, atrophic vagina history, HPV infection, lesion sites of the upper vulva and histo-pathological changes are the risk factors that lead to vulvar cancer. Vulvar nonneoplastic epithelial disorder, vulvar squamous intraepithelial lesion and vulvar cancer each has distinct epidemiological features. Prompt surgical intervention and subsequent treatments are the key to a better outcome of vulvar cancer.

KEYWORDS:

Vulvar nonneoplastic epithelial disorder; hazardous factors; non-conditional logistic regression.; precancerous lesion; vulvar cancer; vulvar squamous intraepithelial neoplasia

Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Supplemental Content

Full text links

Icon for Ivyspring International Publisher Icon for PubMed Central
Loading ...
Support Center