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Front Genet. 2017 Sep 4;8:110. doi: 10.3389/fgene.2017.00110. eCollection 2017.

Genetics of Tinnitus: Time to Biobank Phantom Sounds.

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Experimental Audiology, Department of Physiology and Pharmacology, Karolinska InstitutetStockholm, Sweden.
Department of Molecular Epidemiology and Biostatistics, Karolinska InstitutetStockholm, Sweden.
Department of Genetics, University of North Carolina, Chapel HillNC, United States.
Department of Psychiatry, University of North Carolina, Chapel HillNC, United States.
Otology & Neurotology Group, Department of Genomic Medicine, Pfizer-Universidad de Granada-Junta de Andalucía Centre for Genomics and Oncology Research (GENyO)Granada, Spain.
Department of Otolaryngology, Instituto de Investigación Biosanitaria ibs.GRANADA, Hospital Virgen de las Nieves, Universidad de GranadaGranada, Spain.


Tinnitus is a common phantom sensation resulting most often from sensory deprivation, and for which little knowledge on the molecular mechanisms exists. While the existing evidence for a genetic influence on the condition has been until now sparse and underpowered, recent data suggest that specific forms of tinnitus have a strong genetic component revealing that not all tinnitus percepts are alike, at least in how they are genetically driven. These new findings pave the way for a better understanding on how phantom sensations are molecularly driven and call for international biobanking efforts.


GWAS (genome-wide association study); genetics; heritability; neuropsychiatry; subtype; tinnitus; whole exome sequencing

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