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Genome Biol. 2017 Sep 19;18(1):177. doi: 10.1186/s13059-017-1317-9.

Genomic imprinting beyond DNA methylation: a role for maternal histones.

Author information

1
Epigenetics Programme, Babraham Institute, Cambridge, CB22 3AT, UK.
2
Centre for Trophoblast Research, University of Cambridge, Cambridge, CB2 3EG, UK.
3
Epigenetics Programme, Babraham Institute, Cambridge, CB22 3AT, UK. Gavin.Kelsey@babraham.ac.uk.
4
Centre for Trophoblast Research, University of Cambridge, Cambridge, CB2 3EG, UK. Gavin.Kelsey@babraham.ac.uk.

Abstract

Inheritance of DNA methylation states from gametes determines genomic imprinting in mammals. A new study shows that repressive chromatin in oocytes can also confer imprinting.

PMID:
28927436
PMCID:
PMC5605981
DOI:
10.1186/s13059-017-1317-9
[Indexed for MEDLINE]
Free PMC Article

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