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Chem Commun (Camb). 2017 Sep 28;53(78):10824-10826. doi: 10.1039/c7cc06409h.

Polymer nanodiscs and macro-nanodiscs of a varying lipid composition.

Author information

1
Biophysics Program and Department of Chemistry, The University of Michigan, Ann Arbor, MI 48109-1055, USA. ramamoor@umich.edu.

Abstract

Polymer lipid nanodiscs have enabled some exciting structural biology and nanobiotechnology applications. The use of a small molecular weight polymer (SMA-EA) has been demonstrated to dramatically increase the size of nanodiscs (up to ∼60 nm diameter). Here, we report the first demonstration of the formation of macro-nanodiscs for a variety of lipids, and solid-state NMR experiments utilizing their magnetic-alignment properties.

PMID:
28926036
PMCID:
PMC5621649
[Available on 2018-09-28]
DOI:
10.1039/c7cc06409h

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