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Cell Res. 2017 Dec;27(12):1407-1408. doi: 10.1038/cr.2017.118. Epub 2017 Sep 19.

Fine-tuning type I IFN signaling: A new chapter in the IFN saga.

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Department of Molecular Immunology, Institute of Industrial Science, The University of Tokyo and Max Planck-The University of Tokyo Center for Integrative Inflammology, Komaba 4-6-1, Meguro-ku, Tokyo 153-8505, Japan.


Type I interferon (IFN) signaling is critical for intracellular antimicrobial programmes, affecting both innate and adaptive immune responses. The paper recently published in Cell demonstrates a new regulatory mechanism of the type I IFN signaling pathway by histone-lysine N-methyltransferase SETD2.

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