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Int J Biol Macromol. 2018 Feb;107(Pt A):713-718. doi: 10.1016/j.ijbiomac.2017.09.043. Epub 2017 Sep 15.

A water-soluble polysaccharide from the roots of Polygala tenuifolia suppresses ovarian tumor growth and angiogenesis in vivo.

Author information

1
Department of Medical Oncology, Harbin Chest Hospital, Harbin 150001, China.
2
Department of Gynecological Oncology, Harbin Medical University Cancer Hospital, Harbin 150040, China.
3
Department of Gastroenterology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
4
Department of Intensive Care Unit, Chinese PLA 211 General Hospital, Harbin 150080, China.
5
Department of Gynecological Oncology, Harbin Medical University Cancer Hospital, Harbin 150040, China. Electronic address: fubinzhang_hrbmu@hotmail.com.

Abstract

PTP, one polysaccharide extracted from the roots of Polygala tenuifolia, has displayed anti-cancer activity in several types of ovarian cancer cells. This study aims to elucidate the structure of PTP and investigate its anticancer effects against SKOV3 xenograft tumor growth in BALB/c mice, as well as the underlying mechanisms involved. GC-MS and NMR data indicate that PTP has a backbone composed of 1,4,6-linked-β-Galp, 1,4-linked-β-Galp and 1,4-linked-β-Glcp, with non-reducing terminal 1-linked-α-Glcp attached to O-6 of 1,4,6-linked-β-Galp. The tumor growth was suppressed in mice following two week's PTP administration (10, 20 and 40mg/kg) due to the induction of apoptosis, as detected by TUNEL assay. Moreover, lower serum VEGF and EGFR levels were observed in BALB/c mice treated with different doses of PTP when compared with that in untreated mice. Also, EGFR, VEGF, and CD34 were decreased in both transcript and protein levels in the tumor-bearing mice upon PTP treatment. Taken together, our data suggest that PTP appears to be a powerful chemopreventive agent for the patients with ovarian cancer, especially at advanced stage.

KEYWORDS:

Antiangiogenesis; Human ovarian cancer; Polygala tenuifolia; Polysaccharide; Vascular endothelial growth factor

PMID:
28923567
DOI:
10.1016/j.ijbiomac.2017.09.043
[Indexed for MEDLINE]

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