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Int J Biol Macromol. 2018 Feb;107(Pt A):713-718. doi: 10.1016/j.ijbiomac.2017.09.043. Epub 2017 Sep 15.

A water-soluble polysaccharide from the roots of Polygala tenuifolia suppresses ovarian tumor growth and angiogenesis in vivo.

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Department of Medical Oncology, Harbin Chest Hospital, Harbin 150001, China.
Department of Gynecological Oncology, Harbin Medical University Cancer Hospital, Harbin 150040, China.
Department of Gastroenterology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Department of Intensive Care Unit, Chinese PLA 211 General Hospital, Harbin 150080, China.
Department of Gynecological Oncology, Harbin Medical University Cancer Hospital, Harbin 150040, China. Electronic address:


PTP, one polysaccharide extracted from the roots of Polygala tenuifolia, has displayed anti-cancer activity in several types of ovarian cancer cells. This study aims to elucidate the structure of PTP and investigate its anticancer effects against SKOV3 xenograft tumor growth in BALB/c mice, as well as the underlying mechanisms involved. GC-MS and NMR data indicate that PTP has a backbone composed of 1,4,6-linked-β-Galp, 1,4-linked-β-Galp and 1,4-linked-β-Glcp, with non-reducing terminal 1-linked-α-Glcp attached to O-6 of 1,4,6-linked-β-Galp. The tumor growth was suppressed in mice following two week's PTP administration (10, 20 and 40mg/kg) due to the induction of apoptosis, as detected by TUNEL assay. Moreover, lower serum VEGF and EGFR levels were observed in BALB/c mice treated with different doses of PTP when compared with that in untreated mice. Also, EGFR, VEGF, and CD34 were decreased in both transcript and protein levels in the tumor-bearing mice upon PTP treatment. Taken together, our data suggest that PTP appears to be a powerful chemopreventive agent for the patients with ovarian cancer, especially at advanced stage.


Antiangiogenesis; Human ovarian cancer; Polygala tenuifolia; Polysaccharide; Vascular endothelial growth factor

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