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Int J Antimicrob Agents. 2018 Jan;51(1):145-150. doi: 10.1016/j.ijantimicag.2017.09.008. Epub 2017 Sep 18.

Complete sequence of pBM413, a novel multidrug resistance megaplasmid carrying qnrVC6 and blaIMP-45 from pseudomonas aeruginosa.

Author information

1
School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China.
2
Department of Laboratory Medicine, First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
3
Department of Laboratory Medicine, First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China. Electronic address: jyksys@126.com.
4
Department of Clinical Pharmacy, College of Pharmacy, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA.
5
School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China; Department of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, MD 21201, USA. Electronic address: zhenbo.xu@hotmail.com.
6
Department of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, MD 21201, USA.

Abstract

This study aimed to characterise a novel multidrug resistance megaplasmid carrying qnrVC6 and blaIMP-45 from Pseudomonas aeruginosa strain Guangzhou-Pae617 isolated from a patient hospitalised in Guangzhou, China, in 2012. The plasmid pBM413 has a length of 423 017 bp and an average G + C content of 56.41%. A qnrVC6 gene flanked by two copies of insertion sequence (IS) elements ISCR1, a multiresistance class 1 integron In786 containing aacA4-blaIMP-45-blaOXA-1-catB3 cassettes, an armA gene, and an aphA7 gene flanked by two copies of IS26 were identified. To our knowledge, this is the first identification of a qnrVC6 gene in P. aeruginosa.

KEYWORDS:

Megaplasmid; Multidrug resistance; Pseudomonas aeruginosa; aacA4–bla(IMP-45)–bla(OXA-1)–catB3; qnrVC6

[Indexed for MEDLINE]

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