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Food Chem Toxicol. 2017 Dec;110:434-442. doi: 10.1016/j.fct.2017.09.020. Epub 2017 Sep 18.

d-limonene ameliorates diabetes and its complications in streptozotocin-induced diabetic rats.

Author information

1
Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, 06100, Ankara, Turkey. Electronic address: mervebacanli@gmail.com.
2
Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, 06100, Ankara, Turkey.
3
Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, 06100, Ankara, Turkey; Karadeniz Technical University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, 61080, Trabzon, Turkey.
4
Ankara University, Faculty of Pharmacy, Department of Pharmacology, 06100, Ankara, Turkey.
5
Hacettepe University, Faculty of Pharmacy, Department of Pharmacognosy, 06100 Ankara, Turkey.

Abstract

It is known that diabetes causes some complications including alterations in lipid profile, hepatic enzyme levels but also it causes oxidative stress. Limonene, a major component of Citrus oils, has important health beneficial effects in lowering the level of oxidative stress due to its antioxidant activity. The aim of this study was to investigate the effects of D-limonene on streptozotocin (STZ)-induced diabetes in Wistar albino rats. For this purpose, DNA damage was evaluated by alkaline comet assay. Changes in the activities of catalase (CAT), superoxide dismutase (SOD), glutathione reductase (GR) and glutathione peroxidase (GSHPx) and the levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), total glutathione (GSH), malondialdehyde (MDA), insulin, total bilirubin and BCA protein, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyl transferase (GGT), high density lipoprotein (HDL), low density lipoprotein (LDL), total cholesterol and triglyceride were also evaluated. D-limonene treatment was found to significantly decrease DNA damage, GR enzyme activities and MDA levels and significantly increase GSH levels and CAT, SOD and GSH-Px enzyme activities and altered lipid and liver enzyme parameters in diabetic rats. According to our results, it seems that D-limonene might have a role in the prevention of the complication of diabetes in rats.

KEYWORDS:

DNA damage; Diabetes; Hepatic enzymes; Lipid profil; Oxidative stress

PMID:
28923438
DOI:
10.1016/j.fct.2017.09.020
[Indexed for MEDLINE]

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