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Cell Immunol. 2017 Nov;321:3-7. doi: 10.1016/j.cellimm.2017.09.004. Epub 2017 Sep 11.

Signals that drive T-bet expression in B cells.

Author information

1
Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States.
2
Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, United States.
3
Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States. Electronic address: cancro@mail.med.upenn.edu.

Abstract

Transcription factors regulate various developmental and functional aspects of B cells. T-bet is a recently appreciated transcription factor associated with "Age-associated B cells" or ABCs, the development of autoimmunity, and viral infections. T-bet expression is favored by nucleic acid-containing antigens and immune complexes and is regulated by interplay between various cytokines, notably, the TFH cytokines IL-21, IL-4 and IFNγ. Adaptive signals by themselves cannot upregulate T-bet; however, they have a synergistic effect on induction of T-bet by innate receptors. The functional role of T-bet+ B cells is unclear, although it is known that T-bet promotes class switching to IgG2a/c. It is likely T-bet serves dichotomous roles in B cells, promoting pathogenic autoreactive antibodies on one hand but mediating microbial immunity on the other, making it a target of interest in both therapeutic and prophylactic settings.

KEYWORDS:

B cell; IFN-gamma; IL21; Signalling; T-bet; TLR

PMID:
28923237
PMCID:
PMC6191851
DOI:
10.1016/j.cellimm.2017.09.004
[Indexed for MEDLINE]
Free PMC Article

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