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J Psychopharmacol. 2017 Oct;31(10):1377-1379. doi: 10.1177/0269881117730660. Epub 2017 Sep 19.

The effect of N-acetylcysteine on brain glutamate and gamma-aminobutyric acid concentrations and on smoking cessation: A randomized, double-blind, placebo-controlled trial.

Author information

1
1 Addiction, Development, and Psychopathology (ADAPT) Laboratory, University of Amsterdam, Amsterdam, the Netherlands.
2
2 Amsterdam Institute for Addiction Research, University of Amsterdam, Amsterdam, the Netherlands.
3
3 Arkin Mental Health, Amsterdam, the Netherlands.
4
4 Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Australia.
5
5 Centre for Youth Mental Health, The University of Melbourne, Melbourne, Australia.
6
6 Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands.

Abstract

Using data form a 14-day double-blind trial with 48 smokers randomized to either N-acetylcysteine (2400 mg) or placebo, we tested the effect of N-acetylcysteine on glutamate and gamma-aminobutyric acid concentrations in the dorsal anterior cingulate cortex and on smoking cessation. Smoking related behaviors and neurotransmitter concentrations in the dorsal anterior cingulate cortex were assessed before and after treatment. Forty-seven non-smoking males served as baseline controls. Smokers showed higher baseline glutamate but similar gamma-aminobutyric acid concentrations than non-smokers. There were no treatment effects on dorsal anterior cingulate cortex neurotransmitter concentrations, smoking cessation, craving, or withdrawal symptoms. These results confirm glutamate disbalance in smokers, but not efficacy of N-acetylcysteine.

KEYWORDS:

N-acetylcysteine; Proton magnetic resonance spectroscopy; gamma-aminobutyric acid; glutamate; smoking cessation; tobacco dependence

PMID:
28922968
PMCID:
PMC5639948
DOI:
10.1177/0269881117730660
[Indexed for MEDLINE]
Free PMC Article

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