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Biomed Pharmacother. 2017 Nov;95:1051-1058. doi: 10.1016/j.biopha.2017.08.122. Epub 2017 Sep 13.

Molecular mechanisms of anticancer effects of Glucosamine.

Author information

1
Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: fatemezahedii@gmail.com.
2
Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: dalirr911@mums.ac.ir.
3
Pharmaceutical Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: karimig@mums.ac.ir.
4
Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: jamialahmadikh@mums.ac.ir.

Abstract

Glucosamine is an amino sugar that is produced naturally in human body. It is an essential carbohydrate component of many cellular glycoproteins, glycolipids, and glycosaminoglycans (GAGs). This popular over-the-counter supplement is also found in the exoskeleton of crustaceans. Glucosamine and its derivatives have a long history in medicine for inflammatory conditions specially to relieve arthritis. This dietary supplement has numerous biological and pharmacological properties, including anti-inflammatory, antioxidant, anti-aging, anti-fibrotic, neuroprotective and cardioprotective activities. Many studies have shown that glucosamine has anti-cancer activity through influence on biological pathways involved in cell death, apoptosis, cell proliferation, and angiogenesis. Accordingly, this comprehensive review summarizes anti-cancer molecular mechanisms of glucosamine in details.

KEYWORDS:

Apoptosis; Autophagy; Glucosamine; Inflammation; Molecular signaling

PMID:
28922722
DOI:
10.1016/j.biopha.2017.08.122
[Indexed for MEDLINE]

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