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Angew Chem Int Ed Engl. 2017 Nov 6;56(45):14267-14271. doi: 10.1002/anie.201708573. Epub 2017 Oct 4.

A Redox Modulatory Mn3 O4 Nanozyme with Multi-Enzyme Activity Provides Efficient Cytoprotection to Human Cells in a Parkinson's Disease Model.

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Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore-, 560012, India.
Department of Biochemistry, Indian Institute of Science, Bangalore-, 560012, India.
Center for Nanoscience and Engineering, Indian Institute of Science, Bangalore-, 560012, India.


Nanomaterials with enzyme-like activities (nanozymes) attracts significant interest due to their therapeutic potential for the treatment of various diseases. Herein, we report that a Mn3 O4 nanozyme functionally mimics three major antioxidant enzymes, that is, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) and the multienzyme activity is size as well as morphology-dependent. The redox modulatory effect of Mn3 O4 plays a crucial role in protecting the cells from MPP+ induced cytotoxicity in a Parkinson disease (PD)-like cellular model, indicating that manganese-based nanomaterials having multi-enzyme activity can robustly rescue the cells from oxidative damage and thereby possess therapeutic potential to prevent ROS-mediated neurological disorders.


biomimetic chemistry; enzyme catalysis; manganese; nanocatalysis; nanozymes


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