Send to

Choose Destination
Magn Reson Med. 2018 May;79(5):2738-2744. doi: 10.1002/mrm.26917. Epub 2017 Sep 16.

The role of whole-brain diffusion MRI as a tool for studying human in vivo cortical segregation based on a measure of neurite density.

Author information

Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australia.
Florey Department of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia.
Department of Medicine, Austin Health and Northern Health, University of Melbourne, Melbourne, Victoria, Australia.
iMec-Vision Lab, Department of Physics, University of Antwerp, Belgium.
Centre for the Developing Brain, King's College London, London, UK.
Department of Biomedical Engineering, King's College London, London, UK.



To investigate whether diffusion MRI can be used to study cortical segregation based on a contrast related to neurite density, thus providing a complementary tool to myelin-based MRI techniques used for myeloarchitecture.


Several myelin-sensitive MRI methods (e.g., based on T1 , T2 , and T2*) have been proposed to parcellate cortical areas based on their myeloarchitecture. Recent improvements in hardware, acquisition, and analysis methods have opened the possibility of achieving a more robust characterization of cortical microstructure using diffusion MRI. High-quality diffusion MRI data from the Human Connectome Project was combined with recent advances in fiber orientation modeling. The orientational average of the fiber orientation distribution was used as a summary parameter, which was displayed as inflated brain surface views.


Diffusion MRI identifies cortical patterns consistent with those previously seen by MRI methods used for studying myeloarchitecture, which have shown patterns of high myelination in the sensorimotor strip, visual cortex, and auditory areas and low myelination in frontal and anterior temporal areas.


In vivo human diffusion MRI provides a useful complementary noninvasive approach to myelin-based methods used to study whole-brain cortical parcellation, by exploiting a contrast based on tissue microstructure related to neurite density, rather than myelin itself. Magn Reson Med 79:2738-2744, 2018. © 2017 International Society for Magnetic Resonance in Medicine.


brain; cortex; diffusion MRI; fiber orientation distribution; myeloarchitecture; parcellation


Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center