Format

Send to

Choose Destination
J Autism Dev Disord. 2018 Jan;48(1):137-150. doi: 10.1007/s10803-017-3304-0.

Association Between Air Pollution Exposure, Cognitive and Adaptive Function, and ASD Severity Among Children with Autism Spectrum Disorder.

Author information

1
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
2
Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, 624 N. Broadway, HH833, Baltimore, MD, 21205, USA. hvolk1@jhu.edu.
3
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
4
Sonoma Technology Inc., Petaluma, CA, USA.
5
Department of Public Health Sciences, University of California, Davis, CA, USA.

Abstract

Prenatal exposure to air pollution has been associated with autism spectrum disorder (ASD) risk but no study has examined associations with ASD severity or functioning. Cognitive ability, adaptive functioning, and ASD severity were assessed in 327 children with ASD from the Childhood Autism Risks from Genetics and the Environment study using the Mullen Scales of Early Learning (MSEL), the Vineland Adaptive Behavior Scales (VABS), and the Autism Diagnostic Observation Schedule calibrated severity score. Estimates of nitrogen dioxide (NO2), particulate matter (PM2.5 and PM10), ozone, and near-roadway air pollution were assigned to each trimester of pregnancy and first year of life. Increasing prenatal and first year NO2 exposures were associated with decreased MSEL and VABS scores. Increasing PM10 exposure in the third trimester was paradoxically associated with improved performance on the VABS. ASD severity was not associated with air pollution exposure.

KEYWORDS:

Air pollution; Autism spectrum disorder; Cognitive impairments; Mullen scales of early learning; Vineland adaptive behavioral scale

PMID:
28921105
PMCID:
PMC5764162
DOI:
10.1007/s10803-017-3304-0
[Indexed for MEDLINE]
Free PMC Article

MeSH terms, Substance, Grant support

MeSH terms

Substance

Grant support

Supplemental Content

Full text links

Icon for Springer Icon for PubMed Central
Loading ...
Support Center