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Zhongguo Zhong Yao Za Zhi. 2016 Aug;41(16):3009-3015. doi: 10.4268/cjcmm20161611.

[In vitro transdermal permeation and penetration properties for transfersomes of brucine].

[Article in Chinese]
Wu Y1,2, Chen J2, Fang Y1,3, Dong J2.

Author information

1
Drum Tower Clinical College of Integrative Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210008, China.
2
Pharmaceutical Research Laboratory, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
3
Affiliated Drum Tower Hospital of Medical College of Nanjing University, Nanjing 210008, China.

Abstract

To prepare the liposomes and transfersomes of brucine, characterize their pharmaceutical properties, and compare their in vitro transdermal permeation properties. The liposomes and transfersomes of brucine were prepared by ammonium sulfate gradient method to investigate their pharmaceutical properties such as the particle size, encapsulation efficiency and deformation. The transdermal permeation properties in vitro of liposome and transfersomes from different prescriptions were compared by using modified Franz-diffustion cells with rat skin as the transdermal barrier. The results showed that the particle size of liposomes and transfersomes for brucine ranged from 100 nm to 150 nm, with even distribution for particle size. As compared with the soybean phosphatidylcholine (SPC) transfersomes, the encapsulation efficiency of complex phospholipid transfersomes was significantly improved. The deformation index of complex phospholipid transfersomes in brucine was 2.09 times and 1.76 times as much as SPC liposomes and SPC transfersomes respectively. The steady state flux of complex phospholipid transfersomes was 3.43 times and 1.41 times as much as SPC liposomes and SPC transfersomes. The steady state flux of the physical mixture of brucine and blank complex phospholipid transfersomes was 2.20 times as much as brucine solution. The concentration of complex phospholipid had effect on transdermal permeation of blank transfersomes. In conclusion, as compared with liposomes, the permeation behavior of transfersomes was significantly improved; complex phospholipid technology can improve the membrane phase behavior of transfersomes, and further improve the deformation index and transdermal flux of transfersomes; in addition, blank transfersomes have promoting effect on transdermal absorption of brucine.

KEYWORDS:

brucine ; complex phospholipid ; in vitro transdermal permeation ; transfersome

PMID:
28920340
DOI:
10.4268/cjcmm20161611
[Indexed for MEDLINE]

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