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Clin Immunol. 2017 Oct;183:273-277. doi: 10.1016/j.clim.2017.09.011. Epub 2017 Sep 14.

Severe Toxoplasma gondii infection in a member of a NFKB2-deficient family with T and B cell dysfunction.

Author information

1
San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), Pediatric Immunohematology Unit, San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy.
2
University Department of Pediatrics, Unit of Immune and Infectious Diseases, Childrens' Hospital Bambino Gesù, Italy.
3
Crs4, Biomedicine, Pula, CA, Italy; IRGB CNR, Cittadella Universitaria, Monserrato, CA, Italy.
4
University Department of Pediatrics, Endocrinology Unit, Childrens' Hospital Bambino Gesù, Italy; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
5
University Department of Pediatrics, Unit of Immune and Infectious Diseases, Childrens' Hospital Bambino Gesù, Italy; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
6
University Department of Pediatrics, Endocrinology Unit, Childrens' Hospital Bambino Gesù, Italy.
7
Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
8
Department of Imaging, Neuroradiology Unit, Childrens' Hospital Bambino Gesù, Italy.
9
Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
10
Immuno-Infectivology and Clinical Trials Research Area, Children's Hospital Bambino Gesù, Rome, Italy.
11
B Cell Physiopathology Unit, Immunology Research Area, Children's Hospital Bambino Gesù, Rome, Italy.
12
Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: rosab@stanford.edu.
13
University Department of Pediatrics, Unit of Immune and Infectious Diseases, Childrens' Hospital Bambino Gesù, Italy; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy. Electronic address: cancrini@med.uniroma2.it.

KEYWORDS:

B cell defect; Immune-dysregulation; NFkB2; STAT5A; T cell defect; Toxoplasmosis

PMID:
28919517
DOI:
10.1016/j.clim.2017.09.011
[Indexed for MEDLINE]

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