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Am J Surg. 2017 Oct;214(4):629-633. doi: 10.1016/j.amjsurg.2017.06.018. Epub 2017 Jun 23.

A multi-institutional analysis of intraoperative radiotherapy for early breast cancer: Does age matter?

Author information

1
Moffitt Cancer Center, Tampa, USA.
2
The Cleveland Clinic, Cleveland, OH, USA.
3
Alta Bates Summit Medical Center, Oakland, CA, USA.
4
Northwestern Medicine, Chicago, IL, USA.
5
Community Physician Network Breast Care, Community Health Network, Indianapolis, IN, USA.
6
Mercy Medical Center, Baltimore, MD, USA.
7
Ashikari Breast Center, Dobbs Ferry, NY, USA.
8
The Sentara Dorothy G. Hoefer Comprehensive Breast Center, Newport News, VA, USA.
9
Advocate Good Shepherd Hospital, Barrington, IL, USA.
10
University of California Irvine Medical Center, Irvine, CA, USA.
11
Princess Margaret Cancer Centre, Toronto, ON, Canada.
12
Sutter Cancer Center, Sacramento, CA, USA.
13
MedStar Georgetown University Hospital, Washington, DC, USA.
14
Loyola University, Maywood, IL, USA.
15
Moffitt Cancer Center, Tampa, USA. Electronic address: Christine.laronga@moffitt.org.

Abstract

BACKGROUND:

Single-session intraoperative radiation therapy (IORT) minimizes treatment demands associated with traditional whole breast radiation therapy (WBRT) but outcomes on local disease control and morbidity among the elderly is limited.

METHODS:

A multi-institutional retrospective registry was established from 19 centers utilizing IORT from 2007 to 2013. Patient, tumor, and treatment variables were analyzed for ages <70 and ≥70.

RESULTS:

We evaluated 686 patients (<70 = 424; ≥70 = 262) who were margin and lymph node negative. Patients <70 were more likely to have longer operative time, oncoplastic closure, higher rates of IORT used as planned boost, and receive chemotherapy and post-operative WBRT. Wound complication rates were low and not significantly different between age groups. Median follow-up was 1.06 (range 0.51-1.9) years for < 70 and 1.01 (range 0.5-1.68) years for ≥ 70. There were 5 (0.73%) breast recurrences (4 in <70 and 1 ≥ 70, p = 0.65) and no axillary recurrences during follow-up.

CONCLUSIONS:

IORT was associated with a low rate of wound complication and local recurrence on short-term follow-up in this cohort.

PMID:
28918848
DOI:
10.1016/j.amjsurg.2017.06.018
[Indexed for MEDLINE]

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