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Inflammopharmacology. 2018 Feb;26(1):87-104. doi: 10.1007/s10787-017-0396-2. Epub 2017 Sep 16.

Anti-inflammatory effects of Ginkgo biloba extract against trimethyltin-induced hippocampal neuronal injury.

Author information

1
Department of Biophysics, Basic Medical Sciences Block, Panjab University, Chandigarh, 160014, India.
2
Department of Biophysics, Basic Medical Sciences Block, Panjab University, Chandigarh, 160014, India. bnehru@pu.ac.in.

Abstract

BACKGROUND:

Despite the immense neuromodulatory potentials of Ginkgo biloba extract as a memory enhancer, its underlying mechanism seems inadequate particularly with regard to its anti-inflammatory properties.

AIM:

The objective of the present study is to investigate the protective potentials of Ginkgo biloba extract (GBE) against hippocampal neuronal injury induced by trimethyltin (TMT), a potent neurotoxicant.

METHODS:

Male SD rats were administered trimethyltin (8.5 mg kg-1 b.wt) single intraperitoneal (i.p.) injection, followed by Ginkgo biloba extract (100 mg kg-1 b.wt i.p) for 21 days.

RESULTS:

The co-administration of GBE with TMT showed marked improvement in cognitive functions. Concomitantly, there was a significant decrease in oxidative stress as evident by reduction in MDA and total ROS levels. In addition, there was a marked suppression of astrocyte activation (GFAP), transcription factor NFκB and proinflammatory cytokines (TNF-α, IL-1α, 1L-6), which were found to be elevated by TMT administration. Histopathological observations showed remarkable improvement in hippocampal neuronal injury in the conjunctive group.

CONCLUSION:

Therefore, it is suggested that Ginkgo biloba extract is an effective agent against trimethyltin-induced hippocampal neuronal loss owing to its antioxidative as well as anti-inflammatory properties.

KEYWORDS:

Cytokines; GFAP; Ginkgo biloba extract; Neuroinflammation; Proinflammatory; Trimethyltin

PMID:
28918573
DOI:
10.1007/s10787-017-0396-2
[Indexed for MEDLINE]

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