Format

Send to

Choose Destination
Talanta. 2018 Jan 1;176:130-139. doi: 10.1016/j.talanta.2017.07.088. Epub 2017 Jul 29.

Staying alive! Sensors used for monitoring cell health in bioreactors.

Author information

1
Tyndall National Institute, Lee Maltings, Mardyke Parade, Cork, Ireland.
2
The National Institute for Bioprocessing Research and Training, Foster Avenue, Mount Merrion, Co. Dublin A94 X099, Ireland.
3
The National Institute for Bioprocessing Research and Training, Foster Avenue, Mount Merrion, Co. Dublin A94 X099, Ireland; School of Chemical and Bioprocess Engineering, University College Dublin, Belfield, Dublin 4 D04 V1W8, Ireland.

Abstract

Current and next generation sensors such as pH, dissolved oxygen (dO) and temperature sensors that will help drive the use of single-use bioreactors in industry are reviewed. The current trend in bioreactor use is shifting from the traditional fixed bioreactors to the use of single-use bioreactors (SUBs). However as the shift in paradigm occurs there is now a greater need for sensor technology to play 'catch up' with the innovation of bioreactor technology. Many of the sensors still in use today rely on technology created in the 1960's such as the Clark-type dissolved oxygen sensor or glass pH electrodes. This is due to the strict requirements of sensors to monitor bioprocesses resulting in the use of traditional well understood methods, making it difficult to incorporate new sensor technology into industry. A number of advances in sensor technology have been achieved in recent years, a few of these advances and future research will also be discussed in this review.

KEYWORDS:

Bioreactor; Capsule technology; Dissolved oxygen; Electrochemical sensors; Microfabrication; Optical sensors; Process analytical technology; Temperature; pH

PMID:
28917732
DOI:
10.1016/j.talanta.2017.07.088
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center