Format

Send to

Choose Destination
Pediatr Res. 2018 Jan;83(1-2):283-290. doi: 10.1038/pr.2017.231. Epub 2017 Oct 18.

Tissue regeneration using endothelial colony-forming cells: promising cells for vascular repair.

Author information

1
Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana.

Abstract

Repairing and rebuilding damaged tissue in diseased human subjects remains a daunting challenge for clinical medicine. Proper vascular formation that serves to deliver blood-borne nutrients and adequate levels of oxygen and to remove wastes is critical for successful tissue regeneration. Endothelial colony-forming cells (ECFC) represent a promising cell source for revascularization of damaged tissue. ECFCs are identified by displaying a hierarchy of clonal proliferative potential and by pronounced postnatal vascularization ability in vivo. In this review, we provide a brief overview of human ECFC isolation and characterization, a survey of a number of animal models of human disease in which ECFCs have been shown to have prominent roles in tissue repair, and a summary of current challenges that must be overcome before moving ECFC into human subjects as a cell therapy.

PMID:
28915234
DOI:
10.1038/pr.2017.231
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center