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Int J Mol Sci. 2017 Sep 15;18(9). pii: E1985. doi: 10.3390/ijms18091985.

Lactoferrin: A Natural Glycoprotein Involved in Iron and Inflammatory Homeostasis.

Author information

1
Department of Public Health and Infectious Diseases, University of Rome La Sapienza, 00185 Rome, Italy. luigi.rosa@uniroma1.it.
2
Department of Public Health and Infectious Diseases, University of Rome La Sapienza, 00185 Rome, Italy. antimo.cutone@uniroma1.it.
3
Department of Public Health and Infectious Diseases, University of Rome La Sapienza, 00185 Rome, Italy. mariastefania.lepanto@uniroma1.it.
4
Department of Gynecological-Obstetric and Urological Sciences, University of Rome La Sapienza, 00185 Rome, Italy. rosalba.paesano@uniroma1.it.
5
Department of Public Health and Infectious Diseases, University of Rome La Sapienza, 00185 Rome, Italy. piera.valenti@uniroma1.it.

Abstract

Human lactoferrin (hLf), an iron-binding multifunctional cationic glycoprotein secreted by exocrine glands and by neutrophils, is a key element of host defenses. HLf and bovine Lf (bLf), possessing high sequence homology and identical functions, inhibit bacterial growth and biofilm dependently from iron binding ability while, independently, bacterial adhesion to and the entry into cells. In infected/inflamed host cells, bLf exerts an anti-inflammatory activity against interleukin-6 (IL-6), thus up-regulating ferroportin (Fpn) and transferrin receptor 1 (TfR1) and down-regulating ferritin (Ftn), pivotal actors of iron and inflammatory homeostasis (IIH). Consequently, bLf inhibits intracellular iron overload, an unsafe condition enhancing in vivo susceptibility to infections, as well as anemia of inflammation (AI), re-establishing IIH. In pregnant women, affected by AI, bLf oral administration decreases IL-6 and increases hematological parameters. This surprising effect is unrelated to iron supplementation by bLf (80 μg instead of 1-2 mg/day), but to its role on IIH. AI is unrelated to the lack of iron, but to iron delocalization: cellular/tissue overload and blood deficiency. BLf cures AI by restoring iron from cells to blood through Fpn up-expression. Indeed, anti-inflammatory activity of oral and intravaginal bLf prevents preterm delivery. Promising bLf treatments can prevent/cure transitory inflammation/anemia/oral pathologies in athletes.

KEYWORDS:

anemia; athletes; cytokines; homeostasis; inflammation; iron; lactoferrin; oral care

PMID:
28914813
PMCID:
PMC5618634
DOI:
10.3390/ijms18091985
[Indexed for MEDLINE]
Free PMC Article

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