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ACS Nano. 2017 Sep 26;11(9):9223-9230. doi: 10.1021/acsnano.7b04348. Epub 2017 Sep 15.

Locally Induced Adipose Tissue Browning by Microneedle Patch for Obesity Treatment.

Zhang Y1,2, Liu Q3, Yu J1,2, Yu S1,4, Wang J1, Qiang L3, Gu Z1,2,5.

Author information

1
Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University , Raleigh, North Carolina 27695, United States.
2
Center for Nanotechnology in Drug Delivery and Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.
3
Department of Pathology and Cell Biology, Naomi Berrie Diabetes Center, Columbia University , New York, New York 10032, United States.
4
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun, Jilin 130022, China.
5
Department of Medicine, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.

Abstract

Obesity is one of the most serious public health problems in the 21st century that may lead to many comorbidities such as type-2 diabetes, cardiovascular diseases, and cancer. Current treatments toward obesity including diet, physical exercise, pharmacological therapy, as well as surgeries are always associated with low effectiveness or undesired systematical side effects. In order to enhance treatment efficiency with minimized side effects, we developed a transcutaneous browning agent patch to locally induce adipose tissue transformation. This microneedle-based patch can effectively deliver browning agents to the subcutaneous adipocytes in a sustained manner and switch on the "browning" at the targeted region. It is demonstrated that this patch reduces treated fat pad size, increases whole body energy expenditure, and improves type-2 diabetes in vivo in a diet-induced obesity mouse model.

KEYWORDS:

adipose tissue; browning agent; drug delivery; microneedle patch; obesity

PMID:
28914527
PMCID:
PMC6812556
DOI:
10.1021/acsnano.7b04348
[Indexed for MEDLINE]
Free PMC Article

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