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J Food Drug Anal. 2017 Jul;25(3):559-566. doi: 10.1016/j.jfda.2016.06.003. Epub 2016 Aug 5.

Lactobacillus pentosus GMNL-77 inhibits skin lesions in imiquimod-induced psoriasis-like mice.

Author information

1
Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung-Hsing University, Taichung, Taiwan.
2
Department of Dermatology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
3
Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung-Hsing University, Taichung, Taiwan; Department of Medical Research and Education, Taichung Veterans General Hospital, Taichung, Taiwan.
4
Department of Food Science, Rutgers University, New Brunswick, NJ, USA; Department of Food Science, National Pingtung University of Science and Technology, Pingtung, Taiwan.
5
Department of Food Science, National Pingtung University of Science and Technology, Pingtung, Taiwan.
6
Research and Development Department, GenMont Biotech Incorporation, Tainan, Taiwan.
7
Department of Food Science, National Pingtung University of Science and Technology, Pingtung, Taiwan. Electronic address: chenyk@mail.npust.edu.tw.

Abstract

Psoriasis, which is regarded as a T-cell-mediated chronic inflammatory skin disease, is characterized by hyperproliferation and poor differentiation of epidermal keratinocytes. In this study, we aimed to determine the in vivo effect of a potentially probiotic strain, Lactobacillus pentosus GMNL-77, in imiquimod-induced epidermal hyperplasia and psoriasis-like skin inflammation in BALB/c mice. Oral administration of L. pentosus GMNL-77 significantly decreased erythematous scaling lesions. Real-time polymerase chain reaction showed that treatment with L. pentosus GMNL-77 significantly decreased the mRNA levels of proinflammatory cytokines, including tumor necrosis factor-alpha, interleukin (IL)-6, and the IL-23/IL-17A axis-associated cytokines (IL-23, IL-17A/F, and IL-22) in the skin of imiquimod-treated mice. In addition, we found that L. pentosus GMNL-77 decreased the spleen weights of the imiquimod-treated group and reduced the numbers of IL-17- and IL-22-producing CD4+ T cells in the spleen. In conclusion, the present study provides insight into the potential use of L. pentosus GMNL-77 in the future treatment of psoriasis.

KEYWORDS:

Lactobacillus pentosus GMNL-77; T cells; cytokines; imiquimod; inflammation; psoriasis

PMID:
28911642
DOI:
10.1016/j.jfda.2016.06.003
[Indexed for MEDLINE]
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