Format

Send to

Choose Destination
J Food Drug Anal. 2015 Mar;23(1):124-129. doi: 10.1016/j.jfda.2014.02.004. Epub 2014 May 24.

In vitro anti-diabetic effect and chemical component analysis of 29 essential oils products.

Author information

1
School of Nutrition, Chung Shan Medical University, Taichung, Taiwan.
2
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.
3
Department of Medical Genetics, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
4
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address: aaronfrc@kmu.edu.tw.
5
School of Nutrition, Chung Shan Medical University, Taichung, Taiwan. Electronic address: wck@csmu.edu.tw.

Abstract

Twenty-nine commercial essential oil (EO) products that were purchased from the Taiwan market, including three different company-made Melissa officinalis essential oils, were assayed on their glucose consumption activity and lipid accumulation activity on 3T3-L1 adipocytes. The EOs of M. officinalis were significantly active in both model assays. By contrast, EOs of peppermint, lavender, bergamot, cypress, niaouli nerolidol, geranium-rose, and revensara did not increase glucose consumption activity from media, but displayed inhibited lipid accumulation activity (65-90% of lipid accumulation vs. the control 100%). Because of the promising activity of M. officinalis EOs, three different products were collected and compared for their gas chromatography chemical profiles and bioactivity. The Western blot data suggest that the key factors of the adenosine monophosphate-activated protein kinase/acetyl-CoA carboxylase pathway can be mediated by M. officinalis EOs. Together with biodata, gas chromatography-mass spectrometry profiles suggested mixtures of citrals and minor compounds of M. officinalis EOs may play an important role on effect of antidiabetes.

KEYWORDS:

Melissa officinalis; antidiabetes; essential oils

PMID:
28911435
DOI:
10.1016/j.jfda.2014.02.004
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center