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J Child Adolesc Psychopharmacol. 2018 Mar;28(2):104-110. doi: 10.1089/cap.2017.0091. Epub 2017 Sep 14.

Quality of Life in Children and Youth with Obsessive-Compulsive Disorder.

Author information

1
1 Department of Pediatrics, University of South Florida , St. Petersburg, Florida.
2
2 Department of Health Policy and Management, University of South Florida , St. Petersburg, Florida.
3
3 Department of Psychiatry and Behavioral Neurosciences, University of South Florida , St. Petersburg, Florida.
4
4 Rogers Memorial Hospital , Tampa, Florida.
5
5 Mind Body Branch, Johns Hopkins All Children's Hospital , St. Petersburg, Florida.
6
6 School of Aging Studies, University of South Florida , St. Petersburg, Florida.
7
7 Department of Psychiatry, The Johns Hopkins University, Baltimore, Maryland.
8
8 Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital , Boston, Massachusetts.

Abstract

OBJECTIVE:

The study examined clinical correlates of quality of life (QoL), impact of treatment on QoL, and predictors of QoL change among children with obsessive-compulsive disorder (OCD).

METHODS:

One hundred forty-two children with primary OCD who were enrolled as part of a larger clinical trial participated. Children were administered a structured diagnostic interview, as well as clinician-administered measures of OCD and depression symptom severity. Children and parents completed reports of QoL, as well as measures of impairment and internalizing and externalizing symptoms. Youth received 10 sessions of family-based cognitive-behavioral therapy (CBT).

RESULTS:

At baseline, QoL was inversely related to obsessive-compulsive symptom severity, impairment, externalizing and internalizing symptoms, and severity of depression symptoms according to children and parents. After CBT, QoL improved according to parent ratings, but not child ratings. None of the predictors examined were associated with changes in QoL scores over time. Impairment, and externalizing and internalizing symptoms predicted QoL after accounting for OCD symptom severity. After accounting for OCD symptoms, externalizing symptoms inversely predicted changes in QoL.

CONCLUSION:

These data suggest that QoL is related to more severe clinical presentation and improves with evidence-based treatment, but QoL improvements may be inversely related to externalizing symptomology.

KEYWORDS:

adolescents; assessment; children; cognitive-behavioral therapy; obsessive-compulsive disorder; quality of life; treatment

PMID:
28910139
PMCID:
PMC5831750
DOI:
10.1089/cap.2017.0091
[Indexed for MEDLINE]
Free PMC Article

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