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Magn Reson Med. 2018 May;79(5):2620-2628. doi: 10.1002/mrm.26913. Epub 2017 Sep 14.

SAR and scan-time optimized 3D whole-brain double inversion recovery imaging at 7T.

Author information

1
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
2
Siemens Healthcare GmbH, Erlangen, Germany.
3
Max Planck Institute for Biological Cybernetics, Tübingen, Germany.
4
Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht, Maastricht University, The Netherlands.
5
Department of Epileptology, University Hospital Bonn, Bonn, Germany.
6
Department of Physics and Astronomy, University of Bonn, Bonn, Germany.

Abstract

PURPOSE:

The aim of this project was to implement an ultra-high field (UHF) optimized double inversion recovery (DIR) sequence for gray matter (GM) imaging, enabling whole brain coverage in short acquisition times ( ≈5 min, image resolution 1 mm3 ).

METHODS:

A 3D variable flip angle DIR turbo spin echo (TSE) sequence was optimized for UHF application. We implemented an improved, fast, and specific absorption rate (SAR) efficient TSE imaging module, utilizing improved reordering. The DIR preparation was tailored to UHF application. Additionally, fat artifacts were minimized by employing water excitation instead of fat saturation.

RESULTS:

GM images, covering the whole brain, were acquired in 7 min scan time at 1 mm isotropic resolution. SAR issues were overcome by using a dedicated flip angle calculation considering SAR and SNR efficiency. Furthermore, UHF related artifacts were minimized.

CONCLUSION:

The suggested sequence is suitable to generate GM images with whole-brain coverage at UHF. Due to the short total acquisition times and overall robustness, this approach can potentially enable DIR application in a routine setting and enhance lesion detection in neurological diseases. Magn Reson Med 79:2620-2628, 2018. © 2017 International Society for Magnetic Resonance in Medicine.

KEYWORDS:

DIR; EPG; SAR; UHF

PMID:
28905416
DOI:
10.1002/mrm.26913

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