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J Clin Microbiol. 2017 Nov;55(11):3283-3291. doi: 10.1128/JCM.00866-17. Epub 2017 Sep 13.

Finegoldia magna Isolated from Orthopedic Joint Implant-Associated Infections.

Author information

1
School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden bo.soderquist@oru.se.
2
Department of Laboratory Medicine, Clinical Microbiology, Örebro University Hospital, Örebro, Sweden.
3
School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
4
Department of Biomedicine, Aarhus University, Aarhus, Denmark.

Abstract

The anaerobic Gram-positive coccus Finegoldia magna is a rare cause of infections of bone and joints. The aim of this study was to describe the microbiological and clinical characteristics of orthopedic implant-associated infections caused by F. magna We retrospectively analyzed samples consisting of anaerobic Gram-positive cocci and samples already identified as F. magna from patients with orthopedic infections. The isolates found were determined to the species level using matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). The antibiotic susceptibility pattern was determined by Etest. Whole-genome sequencing (WGS) was performed. Clinical data were extracted from each patient's journal. In nine patients, orthopedic joint implant-associated infections were identified as being caused by F. magna The isolates were susceptible to most of the antibiotics tested, with the exception of rifampin and moxifloxacin in a few cases. Five of the nine infections were monomicrobial. The most common antibiotic used to treat the infection was penicillin V, but five of the nine patients received a combination of antibiotics. Eight patients underwent surgical treatment, with extraction of the implant performed in seven cases and reimplantation in only two cases. The WGS showed a relatively small core genome, with 126,647 single nucleotide polymorphisms identified within the core genome. A phylogenomic analysis revealed that the isolates clustered into two distinct clades. Orthopedic implant-associated infections caused by F. magna are rare, but the bacteria are generally susceptible to antibiotics. Despite this, surgical treatment combined with long-term antibiotics is often necessary. The WGS analysis revealed a high heterogeneity and suggested the existence of at least two different Finegoldia species.

KEYWORDS:

Finegoldia magna; antibiotic susceptibility test; orthopedic implant-associated infections; prosthetic joint infections; whole-genome sequencing

PMID:
28904182
PMCID:
PMC5654912
DOI:
10.1128/JCM.00866-17
[Indexed for MEDLINE]
Free PMC Article

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